Photo by Ryan Watts
Find hotels in Upstate South Carolina, SC from $66
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Go beyond your typical stay in Upstate South Carolina
Pet friendly
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Our top choices for Upstate South Carolina hotels
Carolina Camp Cedar
Carolina Camp CedarPickens
10.0 out of 10, Exceptional, (3 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
Katlynn
$234 nightly
The price is $260
May 14 - May 15
Total with taxes and fees
Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
9.4 out of 10, Exceptional, (1,005 reviews)
"Lovely place to stay right on the lake. "
Sara
$99 nightly
The price is $110
May 11 - May 12
Total with taxes and fees
Hampton Inn Greer Greenville, SC
Hampton Inn Greer Greenville, SCGreer
9.6 out of 10, Exceptional, (454 reviews)
"great service all around."
Alberto
$118 nightly
The price is $129
Jun 7 - Jun 8
Total with taxes and fees
Inn on the Square, an Ascend Collection Hotel
Inn on the Square, an Ascend Collection HotelUptown Greenwood
9.2 out of 10, Wonderful, (736 reviews)
"Friendly staff, nice facility that is centrally located."
Frederick
$113 nightly
The price is $125
May 31 - Jun 1
Total with taxes and fees
Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
9.0 out of 10, Wonderful, (1,004 reviews)
"This place is tops! The area is great, rooms were wonderful, and amenities were amazing. Definitely plan on staying again asap!"
Valarie Tina
$123 nightly
The price is $135
May 9 - May 10
Total with taxes and fees
Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123Downtown
8.0 out of 10, Very Good, (697 reviews)
"Very pleasant and helpful staff. Comfortable room though fairly small."
William
$88 nightly
The price is $97
May 29 - May 30
Total with taxes and fees
Hampton Inn Gaffney
Hampton Inn GaffneyGaffney
8.8 out of 10, Excellent, (709 reviews)
"Would stay again breakfast was amazing "
Theresa
$82 nightly
The price is $90
May 31 - Jun 1
Total with taxes and fees
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ AreaSeneca
9.4 out of 10, Exceptional, (227 reviews)
"Clean property with friendly staff"
Crystal
$129 nightly
The price is $142
May 14 - May 15
Total with taxes and fees
Holiday Inn Express Gaffney by IHG
Holiday Inn Express Gaffney by IHGGaffney
8.8 out of 10, Excellent, (480 reviews)
"Room very clean staff was great breakfast was really good with lots of options "
melvin
$80 nightly
The price is $87
May 17 - May 18
Total with taxes and fees
Deluxe Inn
Deluxe InnMauldin
10.0 out of 10, Exceptional, (2 reviews)
$63 nightly
The price is $69
May 13 - May 14
Total with taxes and fees
Comfort Inn & Suites Greer - Greenville
Comfort Inn & Suites Greer - GreenvilleGreer
8.6 out of 10, Excellent, (788 reviews)
"Wonderful stay - everything was perfect "
Paula
$110 nightly
The price is $120
May 31 - Jun 1
Total with taxes and fees
Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
9.0 out of 10, Wonderful, (1,195 reviews)
"the breakfast was excellent, the room was very clean and nice size, the ac was good, the staff did a very good job"
Jeffrey
$110 nightly
The price is $121
May 24 - May 25
Total with taxes and fees
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca ClemsonSeneca
9.2 out of 10, Wonderful, (837 reviews)
"Great location and facilities"
Brian
$114 nightly
The price is $125
May 24 - May 25
Total with taxes and fees
Holiday Inn Anderson by IHG
Holiday Inn Anderson by IHGAnderson
8.8 out of 10, Excellent, (724 reviews)
"Great location and very clean."
Amy
$106 nightly
The price is $118
Jun 7 - Jun 8
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.Greenville
8.6 out of 10, Excellent, (216 reviews)
"Friendly staff, good location, quiet"
Allison
$80 nightly
The price is $88
May 13 - May 14
Total with taxes and fees
Quality Inn Clinton - Laurens I-26
Quality Inn Clinton - Laurens I-26Clinton
7.4 out of 10, Good, (546 reviews)
"Clean room, easy parking, we were plenty comfortable."
Christine
$67 nightly
The price is $75
Jun 5 - Jun 6
Total with taxes and fees
Hampton Inn Easley
Hampton Inn EasleyEasley
9.2 out of 10, Wonderful, (708 reviews)
"Great staff, left a lasting impression. "
Jenine
$122 nightly
The price is $136
Jun 7 - Jun 8
Total with taxes and fees
The Inn at Patrick Square
The Inn at Patrick SquareClemson
9.8 out of 10, Exceptional, (843 reviews)
"Very nice hotel - very clean, beautiful decor."
Elizabeth
$159 nightly
The price is $176
May 10 - May 11
Total with taxes and fees
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHGAnderson
9.2 out of 10, Wonderful, (614 reviews)
"Clean rooms, friendly staff, great breakfast options!"
Lauren
$110 nightly
The price is $122
May 17 - May 18
Total with taxes and fees
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University AreaClemson
8.4 out of 10, Very Good, (1,008 reviews)
"Great breakfast and friendly staff made our stay enjoyable."
Lon
$100 nightly
The price is $111
Jun 7 - Jun 8
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Upstate South Carolina
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
9.8 out of 10, Exceptional, (71 reviews)
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Stay near popular Upstate South Carolina attractions
Learn more about Upstate South Carolina
Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.
Photo by Ryan Watts
Open Photo by Ryan Watts
Top Upstate South Carolina Hotel Reviews
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
10/10 Excellent
More cheap stays in Upstate South Carolina
Sleep Inn Spartanburg Southwest
501 South Blackstock Rd Spartanburg SC
$60 nightly
The price is $66 total per night from Jun 7 to Jun 8
$66 total
Jun 7 - Jun 8
Total with taxes and fees
6/10 (598 reviews)
Hotels in Upstate South Carolina with star-rating
4 Star Hotels
35 properties
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